Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies (2024)

Abstract

Background: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. Objective: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. Methods: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected. The biopsied PSLs were categorized as benign or malignant (cutaneous melanoma) based on histopathology. Analyzer scores (0-1.00) for these PSLs were obtained and grouped according to histopathology. Results: At an optimized cutoff score of 0.50, a sensitivity of 56% and a specificity of 74% were achieved. The area under the receiver operating characteristics curve was 0.698, indicating poor accuracy as a diagnostic tool. Limitations: This study had a retrospective design and involved only a single institution. Conclusion: Our study reveals a low sensitivity of the scoring function of this digital dermoscopic image analyzer for detecting cutaneous melanomas. Physicians must apply keen clinical judgment when using such devices in the screening of suspicious PSLs.

Original languageEnglish (US)
Pages (from-to)927-934.e6
JournalJournal of the American Academy of Dermatology
Volume78
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 American Academy of Dermatology, Inc.

Keywords

  • computer-aided diagnosis
  • diagnostic accuracy
  • digital dermoscopy
  • image analysis
  • melanoma
  • pigmented skin lesions
  • screening
  • skin cancer
  • test sensitivity

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  • Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies (1)

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del Rosario, F., Farahi, J. M., Drendel, J., Buntinx-Krieg, T., Caravaglio, J., Domozych, R., Chapman, S., Braunberger, T., Dellavalle, R. P., Norris, D. A., Fathi, R., & Alkousakis, T. (2018). Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies. Journal of the American Academy of Dermatology, 78(5), 927-934.e6. https://doi.org/10.1016/j.jaad.2017.01.049

Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies. / del Rosario, Francis; Farahi, Jessica M.; Drendel, Jesse et al.
In: Journal of the American Academy of Dermatology, Vol. 78, No. 5, 05.2018, p. 927-934.e6.

Research output: Contribution to journalArticlepeer-review

del Rosario, F, Farahi, JM, Drendel, J, Buntinx-Krieg, T, Caravaglio, J, Domozych, R, Chapman, S, Braunberger, T, Dellavalle, RP, Norris, DA, Fathi, R & Alkousakis, T 2018, 'Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies', Journal of the American Academy of Dermatology, vol. 78, no. 5, pp. 927-934.e6. https://doi.org/10.1016/j.jaad.2017.01.049

del Rosario F, Farahi JM, Drendel J, Buntinx-Krieg T, Caravaglio J, Domozych R et al. Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies. Journal of the American Academy of Dermatology. 2018 May;78(5):927-934.e6. doi: 10.1016/j.jaad.2017.01.049

del Rosario, Francis ; Farahi, Jessica M. ; Drendel, Jesse et al. / Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies. In: Journal of the American Academy of Dermatology. 2018 ; Vol. 78, No. 5. pp. 927-934.e6.

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title = "Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies",

abstract = "Background: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. Objective: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. Methods: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected. The biopsied PSLs were categorized as benign or malignant (cutaneous melanoma) based on histopathology. Analyzer scores (0-1.00) for these PSLs were obtained and grouped according to histopathology. Results: At an optimized cutoff score of 0.50, a sensitivity of 56% and a specificity of 74% were achieved. The area under the receiver operating characteristics curve was 0.698, indicating poor accuracy as a diagnostic tool. Limitations: This study had a retrospective design and involved only a single institution. Conclusion: Our study reveals a low sensitivity of the scoring function of this digital dermoscopic image analyzer for detecting cutaneous melanomas. Physicians must apply keen clinical judgment when using such devices in the screening of suspicious PSLs.",

keywords = "computer-aided diagnosis, diagnostic accuracy, digital dermoscopy, image analysis, melanoma, pigmented skin lesions, screening, skin cancer, test sensitivity",

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AU - Farahi, Jessica M.

AU - Drendel, Jesse

AU - Buntinx-Krieg, Talayesa

AU - Caravaglio, Joseph

AU - Domozych, Renee

AU - Chapman, Stephanie

AU - Braunberger, Taylor

AU - Dellavalle, Robert P.

AU - Norris, David A.

AU - Fathi, Ramin

AU - Alkousakis, Theodore

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N2 - Background: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. Objective: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. Methods: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected. The biopsied PSLs were categorized as benign or malignant (cutaneous melanoma) based on histopathology. Analyzer scores (0-1.00) for these PSLs were obtained and grouped according to histopathology. Results: At an optimized cutoff score of 0.50, a sensitivity of 56% and a specificity of 74% were achieved. The area under the receiver operating characteristics curve was 0.698, indicating poor accuracy as a diagnostic tool. Limitations: This study had a retrospective design and involved only a single institution. Conclusion: Our study reveals a low sensitivity of the scoring function of this digital dermoscopic image analyzer for detecting cutaneous melanomas. Physicians must apply keen clinical judgment when using such devices in the screening of suspicious PSLs.

AB - Background: Digital dermoscopic image analysis of pigmented skin lesions (PSLs) has become increasingly popular, despite its unclear clinical utility. Unbiased, high-powered studies investigating the efficacy of commercially available systems are limited. Objective: To investigate the diagnostic performance of the FotoFinder Mole-Analyzer in assessing PSLs for cutaneous melanoma. Methods: In this 15-year retrospective study, the histopathologies of 1076 biopsied PSLs among a total of 2500 imaged PSLs were collected. The biopsied PSLs were categorized as benign or malignant (cutaneous melanoma) based on histopathology. Analyzer scores (0-1.00) for these PSLs were obtained and grouped according to histopathology. Results: At an optimized cutoff score of 0.50, a sensitivity of 56% and a specificity of 74% were achieved. The area under the receiver operating characteristics curve was 0.698, indicating poor accuracy as a diagnostic tool. Limitations: This study had a retrospective design and involved only a single institution. Conclusion: Our study reveals a low sensitivity of the scoring function of this digital dermoscopic image analyzer for detecting cutaneous melanomas. Physicians must apply keen clinical judgment when using such devices in the screening of suspicious PSLs.

KW - computer-aided diagnosis

KW - diagnostic accuracy

KW - digital dermoscopy

KW - image analysis

KW - melanoma

KW - pigmented skin lesions

KW - screening

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Performance of a computer-aided digital dermoscopic image analyzer for melanoma detection in 1,076 pigmented skin lesion biopsies (2024)
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